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Adaptogens
Ashwagandha
Also known as: Withania somnifera · KSM-66 · Sensoril
Moderate Evidence67+ human studies
The best-evidenced adaptogen. Reduces cortisol, improves sleep quality, and supports thyroid function. KSM-66 extract has the best data.
Mechanism of Action
Withanolides modulate cortisol via HPA axis downregulation. GABA-mimetic effects on sleep. Possible thyroid hormone potentiation.
Dosage & Timing
Dose
300–600mg KSM-66 extract
When to take
Evening (or split AM/PM)
Stacks Well With
Caution
May interact with: thyroid-medication