NAD+ Precursors

NR

Also known as: Nicotinamide Riboside · Niagen

Evidence grade: ModerateHow grades work

An alternative NAD+ precursor with more human trial data than NMN. Well-tolerated with strong safety profile.

Mechanism of Action

Converts to NMN then NAD+ via the salvage pathway. Increases NAD+ in blood and tissues.

Doses and timing reported in studies

Context, not a recommendation. Study links for this card are still being added, so check the original trials and talk to your doctor before you take anything, especially with medicines or health conditions.

Range used in trials

300–600mg/day

Timing used in trials

Morning

Stacks Well With

Resveratrol

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Evidence grade

Moderate

Goals

LongevityEnergy

Rubric

How evidence grades work

A grade summarises the strength of the human evidence for a compound or device category. It is not a score, it is not a rating of any brand, and it changes when new studies land.

Strong: Several randomised controlled trials or meta-analyses in people agree on direction, the effect is large enough to matter for the stated outcome, and safety is established over long use.
Moderate: Some human trials, but small, short, or mixed. Plausible benefit, with limited long-term safety data.
Emerging: Mostly animal or mechanism studies, or very small human studies. Interesting, not yet enough to act on.
Weak: Little or contradictory evidence, no benefit shown, or a safety concern outweighs the evidence.