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Vitamins & Minerals
TMG
Also known as: Trimethylglycine · Betaine
Emerging Evidence28+ human studies
A methyl donor that counteracts the methylation depletion caused by NMN/NR supplementation. Often recommended to stack with NAD+ precursors.
Mechanism of Action
Donates methyl groups via BHMT pathway → regenerates SAM (S-adenosylmethionine). Lowers homocysteine.
Dosage & Timing
Dose
500mg–2g/day
When to take
Morning with NAD+ precursor
Evidence Scores
Evidence Quality
C0/100
Safety Profile
A+0/100
Popularity
B0/100